Jeffrey H Kordower Selected Research

Glial Cell Line-Derived Neurotrophic Factor (GDNF)

1/2021	GDNF signaling in subjects with minimal motor deficits and Parkinson's disease.
4/2020	Long-term, stable, targeted biodelivery and efficacy of GDNF from encapsulated cells in the rat and Goettingen miniature pig brain.
1/2020	GDNF and Parkinson's Disease: Where Next? A Summary from a Recent Workshop.
1/2019	Widespread Striatal Delivery of GDNF from Encapsulated Cells Prevents the Anatomical and Functional Consequences of Excitotoxicity.
4/2009	Intrastriatal CERE-120 (AAV-Neurturin) protects striatal and cortical neurons and delays motor deficits in a transgenic mouse model of Huntington's disease.
4/2009	Expression, bioactivity, and safety 1 year after adeno-associated viral vector type 2-mediated delivery of neurturin to the monkey nigrostriatal system support cere-120 for Parkinson's disease.
6/2006	Viral delivery of glial cell line-derived neurotrophic factor improves behavior and protects striatal neurons in a mouse model of Huntington's disease.
6/2003	Structural and functional neuroprotection in a rat model of Huntington's disease by viral gene transfer of GDNF.
1/2003	In vivo gene delivery of glial cell line--derived neurotrophic factor for Parkinson's disease.
1/2002	Neuroprotection for Parkinson's disease using viral vector-mediated delivery of GDNF.

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Jeffrey H Kordower Research Topics

Disease

98	Parkinson Disease (Parkinson's Disease) 04/2022 - 01/2002
19	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2020 - 06/2006
14	Synucleinopathies 01/2022 - 02/2016
13	Huntington Disease (Huntington's Disease) 01/2021 - 01/2002
9	Dyskinesias (Dyskinesia) 01/2020 - 05/2000
8	Inflammation (Inflammations) 01/2021 - 12/2016
6	Alzheimer Disease (Alzheimer's Disease) 01/2021 - 02/2002
5	Neuroinflammatory Diseases 05/2019 - 09/2012
4	Dementia (Dementias) 01/2022 - 02/2002
4	Disease Progression 10/2017 - 05/2006
4	Parkinsonian Disorders (Parkinsonism) 07/2017 - 04/2007
3	Multiple System Atrophy 01/2020 - 05/2015
3	Stroke (Strokes) 01/2019 - 01/2003
2	Demyelinating Diseases (Demyelinating Disease) 01/2021 - 01/2020
2	Dysbiosis 01/2020 - 01/2019
2	Neoplasms (Cancer) 01/2020 - 01/2013
2	Schizophrenia (Dementia Praecox) 01/2018 - 04/2013
2	Gliosis 10/2012 - 06/2010
2	Weight Loss (Weight Reduction) 10/2011 - 10/2007
2	Nerve Degeneration 06/2010 - 08/2008
2	Hypertrophy 04/2009 - 06/2003
2	Cognitive Dysfunction 02/2002 - 02/2002
2	Dystonia (Limb Dystonia) 01/2002 - 05/2000
1	Endotoxemia 01/2020
1	HIV Infections (HIV Infection) 05/2019
1	Epilepsy (Aura) 01/2019
1	Globoid Cell Leukodystrophy (Krabbe Disease) 01/2018
1	Gaucher Disease (Gaucher's Disease) 01/2018
1	Bipolar Disorder (Manic Depressive Psychosis) 01/2018
1	Rupture 10/2017
1	Proteostasis Deficiencies 01/2017
1	Cerebellar Ataxia (Dysmetria) 12/2015
1	Spinocerebellar Ataxias (Spinocerebellar Ataxia) 12/2015
1	Lewy Body Disease (Lewy Body Dementia) 05/2015

Drug/Important Bio-Agent (IBA)

24	Dopamine (Intropin)FDA LinkGeneric 04/2022 - 02/2005
23	alpha-SynucleinIBA 01/2022 - 09/2003
20	Proteins (Proteins, Gene)FDA Link 01/2022 - 06/2003
20	SynucleinsIBA 12/2021 - 01/2011
10	Glial Cell Line-Derived Neurotrophic Factor (GDNF)IBA 01/2021 - 01/2002
10	NeurturinIBA 01/2020 - 05/2007
7	Nerve Growth Factors (Neurotrophins)IBA 09/2014 - 07/2007
6	Tyrosine 3-Monooxygenase (Tyrosine Hydroxylase)IBA 01/2020 - 08/2007
6	Levodopa (L Dopa)FDA LinkGeneric 01/2020 - 01/2006
5	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2018 - 08/2006
5	polyglutamineIBA 10/2017 - 06/2003
3	Biomarkers (Surrogate Marker)IBA 01/2021 - 05/2012
3	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2020 - 05/2007
3	Amyloid (Amyloid Fibrils)IBA 11/2019 - 10/2010
3	EndotoxinsIBA 01/2019 - 01/2011
3	LigandsIBA 01/2019 - 12/2002
3	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 12/2016 - 04/2007
3	PrionsIBA 08/2016 - 07/2014
3	salicylhydroxamic acid (SHAM)IBA 08/2015 - 11/2009
3	Peptides (Polypeptides)IBA 09/2012 - 11/2007
3	3-nitropropionic acidIBA 05/2007 - 05/2000
2	Transcription Factors (Transcription Factor)IBA 01/2020 - 09/2012
2	RotenoneIBA 01/2020 - 01/2019
2	Chemokine CCL5IBA 05/2019 - 01/2016
2	Biological ProductsIBA 01/2019 - 07/2017
2	Nerve Growth Factor (NGF)IBA 09/2014 - 05/2005
2	Glial Fibrillary Acidic ProteinIBA 10/2012 - 06/2003
2	Dopamine Plasma Membrane Transport Proteins (Dopamine Transporter)IBA 01/2012 - 05/2008
2	UbiquitinIBA 09/2009 - 05/2008
2	Cholinergic Agents (Cholinergics)IBA 02/2002 - 02/2002
1	Ribosomal Protein S6IBA 01/2021
1	Endopeptidase K (Proteinase K)IBA 01/2021
1	Antisense OligonucleotidesIBA 09/2020
1	Protein AggregatesIBA 01/2020
1	MucinsIBA 01/2020
1	Tyrosine (L-Tyrosine)FDA Link 01/2020
1	Tight Junction ProteinsIBA 01/2020
1	OccludinIBA 01/2020
1	thioflavin TIBA 11/2019
1	Pharmaceutical PreparationsIBA 05/2019
1	Maraviroc FDA Link 05/2019
1	CCR5 Receptors (CCR5 Receptor)IBA 05/2019
1	CytokinesIBA 01/2019
1	Toll-Like Receptor 4IBA 01/2019
1	LipidsIBA 01/2019
1	Neuroprotective AgentsIBA 01/2018
1	Single-Domain AntibodiesIBA 01/2018
1	Psychosine (Galactosylsphingosine)IBA 01/2018
1	GlycosphingolipidsIBA 01/2018
1	GalactosylceramidaseIBA 01/2018
1	EnzymesIBA 01/2018
1	Protein Isoforms (Isoforms)IBA 11/2017
1	Amyloidogenic ProteinsIBA 10/2017
1	Amphetamine (Amfetamine)FDA LinkGeneric 01/2017
1	Indicators and Reagents (Reagents)IBA 01/2017
1	Monocarboxylic Acid TransportersIBA 12/2016
1	MSDC-0160IBA 12/2016
1	Ataxin-1IBA 12/2015

Therapy/Procedure

30	Therapeutics 04/2022 - 02/2002
9	Transplantation 04/2022 - 09/2003
5	Injections 11/2019 - 05/2000
4	Cell Transplantation 01/2020 - 07/2006
3	Cell- and Tissue-Based Therapy (Cell Therapy) 01/2021 - 01/2012
3	Deep Brain Stimulation 01/2018 - 10/2007
1	Immunotherapy 12/2019
1	Oral Administration 05/2019